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Exam 12: Protein Sorting and Transport

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Question 1

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The signal sequence that targets a nascent polypeptide and its mRNA to the rough ER is rich in _______ amino acids.

A) positively charged
B) negatively charged
C) hydrophilic
D) hydrophobic

E) B) and C)
F) All of the above

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Question 2

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In polarized epithelial cells, proteins may be specifically targeted to what two membrane domains?

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The apical...

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Question 3

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The transcription factors that direct the unfolded protein response are _______ and _______.

The lumen of the ER is equivalent topologically to the

How many Rab proteins have been shown to play a specific role in vesicular transport?

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal sequence

As they emerge from the ribosome, signal sequences are recognized and bound by

In cisternal maturation, the carriers for cargo protein transport through the Golgi apparatus are the Golgi _______.

What happens to a glycoprotein in the ER lumen if it cannot be folded correctly?

The major function of the hydrophobic sequence at the amino terminals of proteins that are to be secreted from eukaryotic cells is to target those proteins to the rough ER.

N-linked oligosaccharides are added in the _______ and modified in the _______.

Synaptic vesicles use a special mode of fusion that is completely different from regulated secretion in a typical secretory cell.

What is the likely transport pathway for lysosomal hydrolases in patients with I-cell disease?

If secretory proteins are isolated from secretory vesicles and injected into the cytosol, they will

The main method by which a cell gets rid of old, worn-out organelles is exocytosis.

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -Protein disulfide isomerase

Lysosomes digest

The three major classes of vesicle coat proteins are _______, _______, and _______.

In some proteins, the only transmembrane sequence is located C-terminally in the protein. These proteins are recognized by

Describe the role of each of the following in targeting and processing proteins in the endoplasmic reticulum. -A signal recognition particle (SRP)